Oral Tissue Regeneration

At the root of the problem

This type of approach involves the  reactivation of the dynamics of periodontal tissue restoration. The goal will therefore be to act at the root of the problem by focusing primarily on causes etiological of the problem itself.

Bio-detox and Bio-stimulation

The rehabilitation process is developed in two steps: the Bio-detox and the phase of Bio-stimulation. The first phase is characterized by the intake of draining orally, while in the second phase substances for topical use are used.

As with all good things, this process also takes some time, but the results are usually very promising.

By acting on cellular vitality and restoring the physiological balances that support it, this approach slows down and reverses the phenomenon of?aging  understood as a manifestation of a wider imbalance of the systems that regulate the main functions of the organism.

There are 2 distinct therapeutic moments (steps 1 and steps 2) which can be applied in succession or in parallel, based on the personalized treatment strategy on each patient.

STEP 1 ? BIO-DETOX: provides a systemic oral therapy, aimed at draining toxins from the extracellular matrix.

STEP 2 ? BIO-STIMULATION: consists of a local therapy, aimed at the bio-stimulation of cell turnover processes. It exponentially amplifies its effectiveness, thanks to the detoxification of the periodontal tissue that took place during the steps of bio-detox.

Both steps provide for the use of solutions that act at multiple levels due to the effect of multi-component drugs of natural origin and low-dose biotech molecules, capable of finely modulating the physiological mechanisms that regulate tissue aging, while ensuring high tolerability.

THE SYSTEMIC AGING PROCESS

Clinical studies show that, when the homeostatic equilibrium parameters are altered, an inflammatory process is triggered on the one hand, a histological decline on the other and both contribute significantly to the aging process of the tissues. A? Killer? silent is at the origin of many of the mechanisms that underlie the processes of aging cellular and tissue: the Low Grade Chronic Infiammation. Silent and asymptomatic, it progressively leads to histological alterations of the extracellular matrix, compromising the normal flow of nutrients and signal molecules from the vessels to the cells. The result will be a loss of tissue vitality.

Up to the age of 25/30, the ability to independently recover the homeostatic balance is high, but subsequently it becomes increasingly weaker until it deteriorates after the age of 50. It is possible, by acting in prevention or restoration, to maintain this capacity for as long as possible or reverse its trend.

STEP 1: BIO-DETOX

Il bio-detox reduces chronic inflammatory phenomena, one of the main causes of aging, through a drainage action of the extracellular matrix, to be enhanced, when necessary, also with lymphatic and emunctorial drainage.

The bio-detox is done by drugs multi-component and multi-target, based on selected substances of natural and biological origin. The solution par excellence of steps of bio-detox performs 4 actions at the same time: Anti-inflammatory, Antioxidant, Draining, Detoxifying.

This steps can be further enhanced by biotech drugs based on signal molecules low dose, such as cytokines, able to counteract the overexpression of marker inflammatory, and growth factors, able to stimulate tissue trophism.

STEP 2: BIO-STIMULATION

Bio-stimulation is a multi-level action, useful for counteracting histological decline. The cells of the dermis are stimulated in order to reactivate their natural biological processes and favor theirs turnover.

The bio-stimulation takes place thanks to the synergistic action of drugs multi-component and multi-target, based on low-dose active ingredients, e medical device based on collagen, able to finely modulate the pathophysiological mechanism that causes aging.

BIBLIOGRAPHICAL REFERENCES

1. Barabasi, A. L., Oltvai, Z. N. Z. N. & Barabási, A. L. Network biology: understanding the cell?s functional organization. Nat. Rev. Genet. 5, 101?113 (2004).
2. Barygina V, Becatti M, Lotti T, Moretti S, Taddei N, et al. Treatment with I.ow-dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin. J Dermatol Sci. 2015;79(2): 163-70.
3. Barygina V, Becatti M, Lotti T, Taddei N, Fiorillo C. Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients. J Dermatol Sci. 2016;83(3):242-4.
4. Benvenuto M, Mattera R, Miele MT, Giganti MG, Tresoldi I, Albonici L, Manzari V, et al. E¢ects of a natural multi-component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts. Exp Ther Med. 2019;18(4): 2639-47.
5. De Bellis M. Treatment of wrinkles and skin relaxation with intradermal injections of a complex homeopathic drug (Made). Results of a multicenter study of 681 patients. Biological Medicine 2/2004
6. Del Prete M., Lozzi A. Low Dose Medicine and Inflammation. Low Dosage Pharmacology in the treatment of acute, chronic and autoimmune inflammatory diseases. IPSA Editore 2017
7. Fioranelli M. and Roccia M.G. (2014). Twentyfive years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigm. J. Integr. Cardiol., 1(1): 2-6. 10.15761/JIC.1000102
8. Goldman AW, Burmeister Y, Cesnulevicius K, et al. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, infiammation, and systems biology with the patient?s autoregulatory capacity? Front Physiol. 2015;6:225.
9. Lieleg O, Baumgärtel RM, Bausch AR. Selective filtering of particles by the extracellular matrix: an electrostatic bandpass. Biophys J. 2009;97(6):1569- 1577. 10.15761/JIC.1000102
10. Perra A. et al. L?universo della ?matrice extracellulare?. Rapporti tra Galium -Heel®, plasticità e rigidità del microambiente cellulare. Advanced Therapies n° 15 2018
11. Randelli F, Menon A, Giai Via A, Mazzoleni MG, Sciancalepore F, Brioschi M, Gagliano N. E¢ect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes. Cells. 2018;7(12).
12. Rolman o. et al. Platelet Derived Growth Factor (PDGF) Responsive Epidermis Formed from Human Keratinocytes Transduced with the PDGF? Receptor Gene. Journal of Investigative Dermatology Volume 120, Issue 5, May 2003, Pages 742-749
13. Yalcinkaya E, Celik M, Bugan B. Extracellular matrix turnover: a balance between MMPs and their inhibitors. Arq Bras Cardiol. 2014;102(5):519-520.